Do Oral Cholera Vaccine and Water, Sanitation, and Hygiene Combine to Provide Greater Protection Against Cholera? Results From a Cluster-Randomized Trial of Oral Cholera Vaccine in Kolkata, India
Justin Im e outros, 2024 · Open Forum Infectious Diseases
Living in a household assigned to oral cholera vaccination reduced the 5-year incidence of culture-confirmed cholera by 54%.
Estimativa · protective effectiveness against cholera, %
54,0 [42,0; 64,0]
% (protective effectiveness)
p < .001
- Desenho
- Experimento aleatório por conglomerados. Cluster RCT (3,933 dwelling clusters)
- População
- Residents aged 1 year and older in an urban slum in Kolkata, India, followed for 5 years (2006–2011)
- Amostra
- 106.879 · individuals enrolled across 3,933 dwelling clusters
Onde está o número
RESULTS > PE Against Cholera Associated With OCV Vaccination; Table 2, row 'OCV', column 'Adjusted PE (95% CI)'
Residence in an OCV household was associated with a crude PE of 55% (95% CI, 43%–64%; P < .001) and an adjusted PE of 54% (95% CI, 42%–64%; P < .001; Table 2).
Contexto
What changed: Dwellings were cluster-randomized to two doses of oral cholera vaccine (Shanchol) or placebo, with household WASH evaluated at baseline. Comparison: Residents of households in OCV clusters versus placebo clusters, adjusting for WASH and baseline covariates. Limits: Diarrheal surveillance was passive and only captured cases severe enough to seek clinical care.
Caminho no grafo
- FamíliaProvisão direta
- TipoProvisão de serviço público
- MecanismoAdoção de cuidados preventivos de saúde
- ResultadoDoença diarreica
- EixoSaúde
MAGI só cita evidência deste instrumento
Lugares do estudo
- Kolkata · Município · IN
- Licença
- CC-BY
- Revisão
- Extraído por máquina, não revisadoExtraído por: gemini-3.8-flash, 2026-10-23